| Title | Date | Views | Brief Description |
|---|
| Sexual dimorphism in sepsis susceptibility: Effects of reproductive hormones on microbial pattern recognition receptor expression |
2010 |
214 |
Sex-based differences in innate immune responses to bacterial infection are evident in human patients and animal models of disease. Females are less susceptible to the development of bacterial infections and subsequent bacteremia and/or sepsis whil... |
| Intracellular pattern recognition receptors underlie inflammatory responses of glial cells to central nervous system pathogens |
2009 |
311 |
There is growing appreciation that the resident glial cells of the CNS, in particular microglia and astrocytes, are important participants in the generation of inflammation during brain infection. However, the mechanisms by which these cell types p... |
| Newly described cytosolic pattern recognition receptors mediate inflammatory glial responses to neurotropic viruses |
2012 |
421 |
The rapid onset of potentially lethal neuroinflammation is a defining feature of viral encephalitis. Glial cells are ideally positioned to respond to invading pathogens of the central nervous system (CNS) and produce key inflammatory mediators follow... |